In a growing proportion of diabetic foot ulcers are being diagnosed as neuro-ischaemic. Management of this type of wound is complex, requiring prompt referral, debridement where indicated, appropriate footwear, offloading, dressings and the treatment of infection. Until recently, no drug or device had been demonstrated to effectively treat neuro-ischaemic foot ulcers. The discovery that matrix metalloproteinases are involved has led to the identification and study of nano oligosaccharide factor, which shows promise in treating this challenging condition.
