Scleroderma-like skin induration (SLSI) induced by taxane-based anticancer agents is an adverse effect of chemotherapy that typically affects the extremities, especially the lower legs. Skin induration often remains after chemotherapy is complete, with a significant decrease in the patient’s quality of life and the potential for severe restrictions in joint mobility. Treatment options are limited and often only of partial benefit. We would like to present our therapeutic approach to SLSI and a case of SLSI after breast cancer treatment that was successfully treated with complex physical therapy (CPT).