Objective: To evaluate the safety and efficacy of Retro-Tec Dressings (RTD) in 50 patients with chronic wounds. Methodology: 50 patients with wounds who were ambulatory and met the inclusion criteria were selected. The study was comprised of a screening and baseline stage during which the wounds were assessed. Medical history, as well as previous wound treatments, were assessed and follow-up visits arranged three times per week. The baseline visit included the assessment of wound size and infection. The rate of wound closure was measured in terms of percentage reduction in area, per treatment day. Results: Plantar foot ulcers had a complete close rate of 41%, dorsal foot ulcers 56%, toe ulcers 80%, venous leg ulcers 50% and pressure injury 67% within 6 months. Conclusion: It appears that the components gentian violet, methylene blue and silver form an efficient antimicrobial dressing. The applied RTD wound dressings were effective in managing challenging wounds that showed signs of infections.