As is the case in many countries worldwide, chronic wounds are a major healthcare burden in Asia and provide significant clinical challenges for healthcare workers. Devitalized tissue (slough and eschar) is particularly prevalent in chronic wounds, delaying their healing. Critical to the successful treatment of these wounds is the removal of the devitalized tissue by debridement and the preparation of the wound bed to enable healing progression. This report documents the use of HydroClean® mini in the treatment of six patients with a variety of chronic wounds and shows how this dressing effectively debrided the wounds, supporting wound bed preparation and healing advancement.