This comparative evaluation was conducted with the objective to evaluate the performance reliability of four-cuff digital oscillometric device (DOD) for automated ankle-brachial systolic index (ABSI) measurement in comparison with the standard manual Doppler method that is presently used in the Wound Care Unit of Hospital Kuala Lumpur. (WCUHKL) The DOD used is equipped with four cuffs for automated measurement (left/right brachia and left/right ankle). There were 31 patients from the WCUHKL involved in this comparative evaluation. The ABSI of each patient, left and right respectively, are determined using both Doppler method and DOD method as described in the methodology section. Statistical results from the comparative evaluation shows that the DOD is able to produce equivalent ABSI measurements as the Doppler method. Moreover, the DOD demonstrated a higher consistency in this comparative evaluation as it was able to detect 67% more peripheral artery disease (PAD) cases, which was verified positive by Hospital Kuala Lumpur vascular team. Furthermore, it also provides a range of additional advantages that would make the measurement of ABSI more reliable and convenient for screening of PAD.