Objective: To evaluate the efficacy of integrated Negative Pressure Wound Therapy with instillation (NPWTi) on a stage IV pressure injury for a patient with a 10-year history of diabetes mellitus. Methods: A patient with diabetes mellitus and a stage IV pressure injury was admitted to the medical department. The TIME concept was followed to assess the wound. An automated volumetric wound cleansing solution integrated with NPWTi was applied post-op after debridement. Results: Visible granulation of the wound bed was seen. Undermining, tunneling, bone and tendons were sealed as the granulation tissues proliferated. Sloughs and necrotic tissues were reduced, the wound bed appeared beefy red, moist and the wound edges progressively became smaller at each cycle of dressing change. After 6 weeks of continuous efforts, the wound had granulated well enough for skin grafting. Conclusion: The use of NPWTi quickens the process of wound healing and enhances patients’ quality of life.