Super-oxidized solution (SOS) is widely known for its effectiveness in aiding chronic wounds to heal compared with other traditional antiseptic solutions. There is a growing body of literature that recognizes the role of SOS in wound management, but studies on their efficacy toward biofilms are scarce. In this paper, we provide a short review on the effectiveness of SOS in biofilm removal. In addition, SOS (HYDROCYN aqua^®) was tested against Pseudomonas aeruginosa biofilm and achieved more than 99.999% reduction of biofilm within 15 minutes of exposure. Within the confines of this review, SOS was found to be effective in eradicating biofilms.