In this era of civilisation, modern societies are beginning to reconsider holistic remedies used millennia ago in spite of various technologic and strategic advances. Several studies have shown that the standardised extract of DermaXan (Mangosteen; Garcinia mangostana) pericarp has antibacterial effect, high antioxidant and anti-inflammatory effect. The aim of this on-going study is to assess the wound healing activity of DermaXan (Garcinia mangostana) pericarp extract, Spray 8. We selected 11 patients by simple randomisation at the Wound Care Unit, Department of Internal Medicine, Hospital Kuala Lumpur. They had various wound aetiology and medical background. All the wounds were cleansed using distilled water and debridement was done when necessary. Spray 8 was sprayed on before the wound was covered with a foam dressing. The results show that Spray was effective at reducing wound size and improving healing in both diabetic and non-diabetic ulcers. There were no adverse reactions or allergies reported. However, the sample size in this pilot study was comparatively small, due to the limitation of subject availability. A much larger study is needed to show statistically significant results.