Aim: The objective of this study is to evaluate the safety and efficacy of a negative pressure wound therapy (NPWT) device in trauma and other complex wounds. Methods: The present clinical study is a prospective, interventional study conducted at a tertiary care center. NPWT was applied and the Bates-Jensen Score was calculated to assess the improvement in wound healing outcomes. Results: We assessed 22 patients. The outcomes demonstrated that NPWT treatment reduced Bates-Jensen score when compared with the baseline score. Conclusion: This indicates that NPWT therapy facilitates wound healing by increasing granulation tissue formation and lowering wound exudate levels.