Prevention and appropriate management of wound infection is central to promote the healing process. While not all wounds will necessitate use of systemic antibiotics, some may benefit from the use of topical antimicrobials as part of a holistic standard of care. This article describes five different cases, from China, where the clinicians used Technology Lipido-Colloid Silver Non-Adherent (TLC-Ag) dressings as part of their holistic multidisciplinary wound management strategy. The wounds discussed were mainly chronic, including two venous leg ulcers and lymphoedema ulcer, a post-amputation wound as well as a case of pyoderma gangrenosum. Managing these wounds with TLC-Ag as a part of the standard holistic multidisciplinary care provided resulted in positive outcomes for the patients.