Chronic wounds with low healing rate generally lead to decreased in quality of life of patients, financial burden and increased morbidity rate (Järbrink et al, 2016). Thus, wound care management involving a patented 4-in-1 formulation is an aid in the management of chronic wounds. To demonstrate its efficacy, seven patients were chosen, four with a venous leg ulcer, two with a diabetic foot ulcer and 1 with a pressure ulcer. All the wounds were cleaned, debrided and then the silicon dioxide, silver ions, chlorhexidine and hyaluronic acid cream (KAdermin cream) was applied as the primary dressing, with a non-adhesive dressing as a secondary dressing. This case series demonstrates that the cream was able to reduce wound size significantly, while eliminating infection signs.