Due to the poor circulatory system, a wound in a person with diabetes can demonstrate a persistent and protracted inflammatory response that results in reduced cellular proliferation and production of growth factors. Photobiomodulation (PBM), also known as low-level light therapy, is an application of light to promote beneficial effects such as reduction of inflammation and tissue regeneration. Promising results have been obtained with the use of blue LED light in the treatment of hard-to-heal wounds, which led us to assess its efficacy on patients with diabetic foot ulcers (DFU), in five patients undergoing treatment at the Kuala Lumpur Hospital Wound Care Unit. All the patients responded to the treatment reaching complete healing or a significant reduction of wound size during the treatment period. Our positive results obtained must be validated by further larger studies.