The condition and moistness of periwound skin has been directly linked to the success of wound bed preparation and wound healing. This study investigates the use of a novel skin cleanser designed to enhance periwound recovery, in a population of 61 patients seeking outpatient care at the wound clinic of Kuala Lumpur General Hospital for lower limb wounds. All patients underwent baseline assessment of their wounds using the TIME assessment technique for the wound bed and the Harikrishna Periwound Skin Classification for periwound skin, followed by treatment with the skin cleanser as well as the appropriate dressings and treatment adjuncts. Of the 61 patients assessed on periwound condition during the 7-month observation period, 3 patients had complete wound healing, 50 patients progressed to healthy wounds, 4 patients had macerated periwound skin and another 4 patients had dry periwound skin after the completion of the trial. All patients with wounds exhibiting inflammation with or without superimposed infection experienced resolution of these issues following use of the skin cleanser.