Polyurethane foam dressings have shown potential in the treatment of acute and chronic wounds due to their unique biomechanical properties. The LOKUS polyurethane foam is a liquid foam dressing previously shown in a small single-centre study to demonstrate high absorptive capability and reliable adhesion to the wound surface. This case series describes the usage of the LOKUS liquid polyurethane foam bandage in the treatment of 47 patients with chronic wounds attending the Wound Clinic of Kuala Lumpur General Hospital over a period of 3 months.