Journal Articles

Moving the chronic wound along the healing trajectory

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Moving the chronic wound along the healing trajectory

Emilio Galea
17 September 2018

In the author’s previous article ‘A Breakthrough in the Management of Neuro-Ischaemic Diabetic Foot Ulcers’ (Galea, 2018), the emphasis was placed on the detrimental effect of elevated levels of matrix metalloproteinases (MMPs) in chronic wounds. The result of altered activities of proteases and their inhibitors lead to an altered healing process and the balance in regulation between the two appears to be disrupted in chronic wounds (Enoch and Price, 2004). However, other attributes are present that may lead to a wound being stuck in the inflammatory phase (Velnar et al, 2009). 


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