This case series investigates the recovery of chronic wounds treated with hyaluronic acid-collagenase (Hyalo4® Start), which facilitates enzymatic debridement, helping prepare the wound bed for healing and closure on top of first-line therapy. We recruited 15 patients with different underlying comorbidities who consented to participate in the case study. Selection criteria include patients with chronic wounds classified as Class 2 and Class 3 according to Harikrishna Periwound Skin Classification (HPSC). Treatment duration varied. The study observed a minimal to 100% reduction in wound size, notably diminished exudate excretion, healthy wound edge, and lower pain score as Hyalo4® Start was applied as part of standard care.